January 21 is the 21st day of the year in the Gregorian calendar. There are 344 days remaining until the end of the year.
763 – The Battle of Bakhamra between Alids and Abbasids near Kufa ends in a decisive Abbasid victory.
1525 – The Swiss Anabaptist Movement is founded when Conrad Grebel, Felix Manz, George Blaurock, and about a dozen others baptize each other in the home of Manz's mother in Zürich, breaking a thousand-year tradition of church-state union.
1535 – Following the Affair of the Placards, French Protestants are burned at the stake in front of the Cathedral of Notre Dame de Paris
1720 – Sweden and Prussia sign the Treaty of Stockholm.
1749 – The Teatro Filarmonico in Verona is destroyed by fire. It is rebuilt in 1754.
1774 – Abdul Hamid I became Sultan of the Ottoman Empire and Caliph of Islam.
1789 – The first American novel, The Power of Sympathy or the Triumph of Nature Founded in Truth by William Hill Brown, is printed in Boston.
1793 – After being found guilty of treason by the French National Convention, Louis XVI of France is executed by guillotine.
1861 – American Civil War: Jefferson Davis resigns from the United States Senate.
1893 – The Tati Concessions Land, formerly part of Matabeleland, is formally annexed to the Bechuanaland Protectorate, now Botswana.
1908 – New York City passes the Sullivan Ordinance, making it illegal for women to smoke in public, only to have the measure vetoed by the mayor.
1911 – The first Monte Carlo Rally takes place.
1915 – Kiwanis International is founded in Detroit.
1919 – A revolutionary Irish parliament is founded and declares the independence of the Irish Republic. One of the first engagements of the Irish War of Independence takes place.
1925 – Albania declares itself a republic.
1931 – Sir Isaac Isaacs is sworn in as the first Australian-born Governor-General of Australia.
1941 – Sparked by the murder of a German officer in Bucharest, Romania, the day before, members of the Iron Guard engaged in a rebellion and pogrom killing 125 Jews.
1948 – The Flag of Quebec is adopted and flown for the first time over the National Assembly of Quebec. The day is marked annually as Québec Flag Day.
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950 – American lawyer and government official Alger Hiss is convicted of perjury.
1954 – The first nuclear-powered submarine, the USS Nautilus, is launched in Groton, Connecticut by Mamie Eisenhower, the First Lady of the United States.
1960 – Little Joe 1B, a Mercury spacecraft, lifts off from Wallops Island, Virginia with Miss Sam, a female rhesus monkey on board.
1960 – Avianca Flight 671 crashes and burns upon landing at Montego Bay, Jamaica killing 37. It is the worst air disaster in Jamaica's history and the first for Avianca.
1960 – A coal mine collapses at Holly Country, South Africa, killing 435 miners.
1968 – Vietnam War: Battle of Khe Sanh: One of the most publicized and controversial battles of the war begins.
1968 – A B-52 bomber crashes near Thule Air Base, contaminating the area after its nuclear payload ruptures. One of the four bombs remains unaccounted for after the cleanup operation is complete.
1971 – The current Emley Moor transmitting station, the tallest free-standing structure in the United Kingdom, begins transmitting UHF broadcasts.
1976 – Commercial service of Concorde begins with the London-Bahrain and Paris-Rio routes.
1981 – Production of the iconic DeLorean DMC-12 sports car begins in Dunmurry, Northern Ireland, United Kingdom.
1997 – The U.S. House of Representatives votes 395–28 to reprimand Newt Gingrich for ethics violations, making him the first Speaker of the House to be so disciplined.
1999 – War on Drugs: In one of the largest drug busts in American history, the United States Coast Guard intercepts a ship with over 4,300 kilograms (9,500 lb) of cocaine on board.
2000 – Ecuador: After the Ecuadorian Congress is seized by indigenous organizations, Col. Lucio Gutiérrez, Carlos Solorzano and Antonio Vargas depose President Jamil Mahuad. Gutierrez is later replaced by Gen. Carlos Mendoza, who resigns and allows Vice-President Gustavo Noboa to succeed Mahuad.
2003 – A 7.6 magnitude earthquake strikes the Mexican state of Colima, killing 29 and leaving approximately 10,000 people homeless.
2004 – NASA's MER-A (the Mars Rover Spirit) ceases communication with mission control. The problem lies in the management of its flash memory and is fixed remotely from Earth on February 6.
2005 – In Belmopan, Belize, the unrest over the government's new taxes erupts into riots.
2009 – Israel withdraws from the Gaza Strip, officially ending a three-week war it had with Hamas. However, intermittent fire by both sides continues in the weeks to follow.
2011 – Anti government demonstrations take place in Tirana, Albania. Five people lose their lives from gunshots, allegedly fired from armed police protecting the Prime Minister's office. To date, no one has been held accountable for the deaths.
2017 – Over 400 cities across America and 160+ countries worldwide participate in a large-scale women's march, on Donald Trump's first full day as President of the United States.
2018 – Rocket Lab's Electron becomes the first rocket to reach orbit using an electric pump-fed engine and deploys three CubeSats.